Pyrroloquinoline Quinone (PQQ) is a vitamin-like compound that has gained attention in recent years for its profound impact on mitochondrial health.¹

Mitochondria are often described as the "powerhouses" of the cell - responsible for producing the energy every organ and tissue needs to function.

Unlike traditional antioxidants that neutralize free radicals only once, PQQ has been shown to regenerate and continue its protective action, and may also stimulate the growth of new mitochondria (a process called mitochondrial biogenesis).²˒³˒⁴

This has major implications for natural energy levels, cognitive function, and healthy aging.⁵

- May stimulate mitochondrial biogenesis
PQQ has been shown in studies to promote the creation of new mitochondria, improving cellular energy production.³˒⁴

- Reduces oxidative stress
PQQ neutralizes harmful free radicals that contribute to the effects of the natural aging process.²

- Supports the brain and nerves
PQQ has been shown to support nerve growth factors and may help maintain healthy cognition in aging dogs.⁵

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide naturally produced by your dog's body. It modulates the endocannabinoid system - not by binding directly to CB1 or CB2 receptors, but by influencing key pathways in the nervous and immune systems.⁶˒⁷˒⁸

It is important to note that PEA is not a cannabinoid itself, and it does not produce any psychoactive effects. Instead, it supports the nervous and immune systems, helping to maintain balance and promote overall well-being.

- PPAR-α activation
PEA binds to peroxisome proliferator-activated receptor alpha (PPAR-α), which helps regulate healthy inflammatory responses and cellular metabolism.⁶

 - Mast cell modulation
PEA helps inhibit mast cell activation, which reduces the release of substances like histamine.⁷

- Endocannabinoid support
Although it doesn’t bind directly to cannabinoid receptors, PEA promotes healthy functioning of the endocannabinoid system indirectly.⁸

What this means for your dog

- Joint comfort and mobility support
- Promotes a healthy inflammatory response
- Promotes healthy immune balance without suppressing the immune system

While PEA primarily addresses joint comfort and PQQ focuses on oxidative stress and cellular energy, they complement each other in key ways:

- Dual Targeting
PEA modulates the nervous system, stabilizes immune cells, and promotes joint comfort while PQQ mops up oxidative byproducts that perpetuate effects of aging. Together, they could offer a more broad array of benefits than either alone.⁹˒¹⁰

- Mitochondrial and Cellular Health
The normal activity and stress of life drains cellular energy. PEA helps reduce this burden, while PQQ stimulates the production of healthier, more resilient mitochondria. This means healthy energy levels and overall better vitality for your dog.³˒⁴