The Amiquip Answers Hub
What is PQQ?
Pyrroloquinoline Quinone (PQQ) is a vitamin-like compound that has gained attention in recent years for its profound impact on mitochondrial health.¹
Mitochondria are often described as the "powerhouses" of the cell - responsible for producing the energy every organ and tissue needs to function.
Unlike traditional antioxidants that neutralize free radicals only once, PQQ has been shown to regenerate and continue its protective action and may also stimulate the growth of new mitochondria (a process called mitochondrial biogenesis).²˒³˒⁴
This has major implications for natural energy levels, cognitive function, and healthy aging.⁵
Potential PQQ Benefits
- May stimulate mitochondrial biogenesis
PQQ has been shown in studies to promote the creation of new mitochondria, improving cellular energy production.³˒⁴
- Reduces oxidative stress
PQQ neutralizes harmful free radicals that contribute to the effects of the natural aging process.²
- Supports the brain and nerves
PQQ has been shown to support nerve growth factors and may help maintain healthy cognition in aging dogs.⁵
What is PEA?
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide naturally produced by your dog's body. It modulates the endocannabinoid system - not by binding directly to CB1 or CB2 receptors, but by influencing key pathways in the nervous and immune systems.⁶˒⁷˒⁸ PEA is also found in every cell in the human body and is a component of human breast milk.
It is important to note that PEA is not a cannabinoid itself, and it does not produce any psychoactive effects. Instead, it supports the nervous and immune systems, helping to maintain balance and promote overall well-being.
Potential PEA Benefits
- PPAR-α activation
PEA binds to peroxisome proliferator-activated receptor alpha (PPAR-α), which helps regulate healthy inflammatory responses and cellular metabolism.⁶
- Mast cell modulation
PEA helps inhibit mast cell activation, which reduces the release of substances like histamine.⁷
- Endocannabinoid support
Although it doesn’t bind directly to cannabinoid receptors, PEA promotes healthy functioning of the endocannabinoid system indirectly.⁸
What this means for your dog
- Joint comfort and mobility support
- Promotes a healthy inflammatory response
- Promotes healthy immune balance without suppressing the immune system
Why does Amiquip combine PQQ and PEA?
While PEA primarily addresses joint comfort and PQQ focuses on oxidative stress and cellular energy, they complement each other in key ways:
- Dual Targeting
PEA modulates the nervous system, stabilizes immune cells, and promotes joint comfort while PQQ mops up oxidative byproducts that perpetuate effects of aging. Together, they could offer a more broad array of benefits than either alone.⁹˒¹⁰
- Mitochondrial and Cellular Health
The normal activity and stress of life drains cellular energy. PEA helps reduce this burden, while PQQ stimulates the production of healthier, more resilient mitochondria. This means healthy energy levels and overall better vitality for your dog.³˒⁴
Lots of dog supplements have 10 or more ingredients. Why does Amiquip only have two?
Many dog supplements are designed like multivitamins: an ingredient for joints, one for the coat, another for the heart, and so on, leading to 10 - 20 active compounds in one chew or scoop.
Sometimes this means your dog may not be getting enough of each ingredient to be effective. Other times the complex blend is potentially problematic for sensitive dogs, or for dogs that already have complex diet requirements. Every added compound increases the risk of a negative reaction.
Rather than adding more and more ingredients to deal with different issues, Amiquip goes straight to one of the foundations of total health and wellbeing: cellular health. By supporting healthy mitochondrial function and promoting joint comfort & mental cognition, Amiquip covers the same body systems as the other supplements with a much simpler, more affordable formula.
Where is Amiquip Made?
Amiquip is manufactured in Topeka, Kansas in a cGMP facility and is lab-tested in the USA.
How much does Amiquip cost?
Amiquip dosage is based on the weight of your dog. Most dogs will take one soft chew per day. Since Amiquip contains 90 chews (measured by weight, not by count), that's only 48 cents per day. If you have a very small dog, they might only require 1/2 chew every other day, which means it's only 12 cents per day!
How do we produce a premium supplement for such an affordable price? Our formula features two groundbreaking active ingredients with multi-system support, making Amiquip an economic choice.
What is PQQ?
Pyrroloquinoline Quinone (PQQ) is a vitamin-like compound that has gained attention in recent years for its profound impact on mitochondrial health.¹
Mitochondria are often described as the "powerhouses" of the cell - responsible for producing the energy every organ and tissue needs to function.
Unlike traditional antioxidants that neutralize free radicals only once, PQQ has been shown to regenerate and continue its protective action and may also stimulate the growth of new mitochondria (a process called mitochondrial biogenesis).²˒³˒⁴
This has major implications for natural energy levels, cognitive function, and healthy aging.⁵
Potential PQQ Benefits
- May stimulate mitochondrial biogenesis
PQQ has been shown in studies to promote the creation of new mitochondria, improving cellular energy production.³˒⁴
- Reduces oxidative stress
PQQ neutralizes harmful free radicals that contribute to the effects of the natural aging process.²
- Supports the brain and nerves
PQQ has been shown to support nerve growth factors and may help maintain healthy cognition in aging dogs.⁵
What is PEA?
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide naturally produced by your dog's body. It modulates the endocannabinoid system - not by binding directly to CB1 or CB2 receptors, but by influencing key pathways in the nervous and immune systems.⁶˒⁷˒⁸ PEA is also found in every cell in the human body and is a component of human breast milk.
It is important to note that PEA is not a cannabinoid itself, and it does not produce any psychoactive effects. Instead, it supports the nervous and immune systems, helping to maintain balance and promote overall well-being.
Potential PEA Benefits
- PPAR-α activation
PEA binds to peroxisome proliferator-activated receptor alpha (PPAR-α), which helps regulate healthy inflammatory responses and cellular metabolism.⁶
- Mast cell modulation
PEA helps inhibit mast cell activation, which reduces the release of substances like histamine.⁷
- Endocannabinoid support
Although it doesn’t bind directly to cannabinoid receptors, PEA promotes healthy functioning of the endocannabinoid system indirectly.⁸
What this means for your dog
- Joint comfort and mobility support
- Promotes a healthy inflammatory response
- Promotes healthy immune balance without suppressing the immune system
Why does Amiquip combine PQQ and PEA?
While PEA primarily addresses joint comfort and PQQ focuses on oxidative stress and cellular energy, they complement each other in key ways:
- Dual Targeting
PEA modulates the nervous system, stabilizes immune cells, and promotes joint comfort while PQQ mops up oxidative byproducts that perpetuate effects of aging. Together, they could offer a more broad array of benefits than either alone.⁹˒¹⁰
- Mitochondrial and Cellular Health
The normal activity and stress of life drains cellular energy. PEA helps reduce this burden, while PQQ stimulates the production of healthier, more resilient mitochondria. This means healthy energy levels and overall better vitality for your dog.³˒⁴
Lots of dog supplements have 10 or more ingredients. Why does Amiquip only have two?
Many dog supplements are designed like multivitamins: an ingredient for joints, one for the coat, another for the heart, and so on, leading to 10 - 20 active compounds in one chew or scoop.
Sometimes this means your dog may not be getting enough of each ingredient to be effective. Other times the complex blend is potentially problematic for sensitive dogs, or for dogs that already have complex diet requirements. Every added compound increases the risk of a negative reaction.
Rather than adding more and more ingredients to deal with different issues, Amiquip goes straight to one of the foundations of total health and wellbeing: cellular health. By supporting healthy mitochondrial function and promoting joint comfort & mental cognition, Amiquip covers the same body systems as the other supplements with a much simpler, more affordable formula.
Where is Amiquip Made?
Amiquip is manufactured in Topeka, Kansas in a cGMP facility and is lab-tested in the USA.
How much does Amiquip cost?
Amiquip dosage is based on the weight of your dog. Most dogs will take one soft chew per day. Since Amiquip contains 90 chews (measured by weight, not by count), that's only 48 cents per day. If you have a very small dog, they might only require 1/2 chew every other day, which means it's only 12 cents per day!
How do we produce a premium supplement for such an affordable price? Our formula features two groundbreaking active ingredients with multi-system support, making Amiquip an economic choice.
How Amiquip Works
Week 1
PQQ – Mitochondrial & Cellular Energy Benefits
PQQ gets to work fast. Rapid tissue distribution within hours kicks off direct mitochondrial ROS scavenging¹.
Activates PGC-1α → 15–25% ↑ mitochondrial DNA in liver, muscle, brain².
NAD⁺ levels rise. Lipid peroxidation drops³.
PEA – Nervous System & Joint Comfort
PEA hits peak plasma in 1–2 hours → modulates mast cells & microglia by 40–60%⁵.
Spinal & circulating mediators drop markedly⁶.
Canines show early gains in mechanical sensitivity & weight-bearing symmetry⁵.
Expected Synergistic Effect when Taken Together
Both quickly dial down oxidative stress + glial activity → perfect setup for new mitochondria.
Week 2
PQQ – Mitochondrial & Cellular Energy Benefits
Mitochondrial biogenesis picks up speed → 30–50% ↑ mtDNA in porcine models².
Complex I–IV & citrate synthase activity climb → β-oxidation ↑, liver triglycerides ↓³.
Nrf2/HO-1 pathway keeps redox balance steady¹.
PEA – Nervous System & Joint Comfort
Microglia settle into resting state → mediators stay suppressed⁶.
Joint mast cell/neutrophil modulation >50% → better locomotor function in dogs⁵.
Early boost in exploratory activity kicks in⁷.
Expected Synergistic Effect when Taken Together
PEA's glial calming shields the mitochondria PQQ's building.
Week 3
PQQ – Mitochondrial & Cellular Energy Benefits
Mitochondrial membrane potential stabilizes → resists Ca²⁺ overload like a champ².
SIRT1/SIRT3 peak → SOD2 & catalase ↑ 25–40%³.
Antioxidant capacity hits stride in 21–28 day supplementation¹.
PEA – Nervous System & Joint Comfort
Nervous system mediators drop 70–80% → COX-2 stays in check⁶.
Immune balance locks in → gait symmetry improves in 4-week canine trials⁵.
Joint comfort scores climb noticeably⁷.
Expected Synergistic Effect when Taken Together
Prime mitochondrial efficiency meets peak nervous system modulation.
Week 4
PQQ – Mitochondrial & Cellular Energy Benefits
Mitochondrial volume density 50–80% above baseline in porcine liver/muscle¹.
AMPK/PGC-1α signaling holds strong → growth performance surges³.
Cellular energy metabolism hits optimal at 28 days².
PEA – Nervous System & Joint Comfort
Microglia & astrocytes stay quiet → joint guarding drops >60%⁵.
Nervous/immune integration → weight-bearing symmetry normalizes⁶.
Daily mobility peaks with micronized formulations⁷.
Expected Synergistic Effect when Taken Together
Top-tier mitochondrial power with rock-solid immune comfort.
Week 5
PQQ – Mitochondrial & Cellular Energy Benefits
New mitochondria resist oxidative hits → 8-oxo-dG stays low².
Cognitive gains emerge in senior dogs → better memory & motor skills⁴.
Systemic antioxidants hold elevated³.
PEA – Nervous System & Joint Comfort
Endogenous PEA mediators stay up → sensitivity thresholds stable⁵.
Nervous system support endures → symmetrical weight-bearing holds⁶.
56-day trials confirm steady joint comfort⁷.
Expected Synergistic Effect when Taken Together
Lasting mitochondrial quality + persistent glial balance.
Week 6
PQQ – Mitochondrial & Cellular Energy Benefits
Mitochondrial density & respiration lock in 25–35% above baseline⁴.
Brain Complex IV ↑ long-term → cognition stays sharp².
Antioxidant protection lingers weeks even after stopping³.
PEA – Nervous System & Joint Comfort
Low-mediator setpoint holds across CNS & periphery → 8+ weeks⁵.
Microglia return to normal surveillance⁶.
Dog cognition & mobility keep improving⁷.
Expected Synergistic Effect when Taken Together
Locked-in result: enduring mitochondrial energy + optimal nervous/immune comfort.
Still have questions? Ask the Amiquip Assistant
Amiquip™ Soft Chews for Dogs (PQQ 6 mg + PEA 200 mg) | 90+ Day Supply
Amiquip™ features a dual-action formula of PQQ (6 mg) to support mitochondrial function and natural energy (plus cognitive support) + PEA (200 mg) for joint comfort and a healthy inflammatory response. 90+ day supply with free USA shipping.
FAQ References
- Misra HS, Rajpurohit YS, Khairnar NP. Pyrroloquinoline-quinone and its versatile roles in biological processes. J Biosci. 2012;37(2):313-25.
- Akagawa M, Nakano M, Ikemoto K. Recent progress in studies on the health benefits of pyrroloquinoline quinone. Biosci Biotechnol Biochem. 2016;80(1):13-22.
- Zhang Q, Ding Y, Guo L, et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through AMPK/PGC-1α signaling pathway in obesity models. Front Mol Biosci. 2023;10:1200025.
- Zhang L, Li S, Zhang Y, et al. Pyrroloquinoline quinone promotes mitochondrial biogenesis and reduces oxidative stress via SIRT1/3 and CREB pathways. Int J Mol Sci. 2023;26(14):6938.
- Chowanadisai W, Bauerly KA, Tchaparian E, et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis in murine cells. FASEB J. 2010;24(6):2405-15.
- Keppel Hesselink JM, de Boer T, Witkamp RF. Palmitoylethanolamide: a natural body-own... Br J Clin Pharmacol. 2013;75(5):1113-23.
- Petrosino S, Iuvone T, Di Marzo V. N-palmitoylethanolamine: Biochemistry and new therapeutic opportunities. Biochimie. 2010;92(6):724-7.
- Lanza M, Durando L, Aranzulla T, et al. Palmitoylethanolamide (PEA) in veterinary medicine: research update and clinical applications. Animals (Basel). 2021;11(4):952.
- Cerrato S, Brazis P, Della Valle MF, Miolo A, Petrosino S, Di Marzo V, et al. Topical palmitoylethanolamide and quercetin for the treatment of canine... BMC Vet Res. 2012;8:23.
- Di Cerbo A, Palmieri B, Iannitti T. Evaluation of the efficacy and safety of palmitoylethanolamide combination in managing pain in dogs: An open-label clinical trial. Vet Sci Res. 2024; (in press).
Timeline References
- Zhang M, Wang Y, Zhang X, et al. Dietary Pyrroloquinoline Quinone Addition Alleviated... Animals (Basel). 2025;15(17):2543.
- Yin Z, Liu Q, Liu S, et al. Pyrroloquinoline quinone regulates the redox status in vitro and in vivo... Nrf2/HO-1 pathway. J Anim Sci Biotechnol. 2021;12(1):77.
- Wang Y, Zhao J, Zhang P, et al. Effects of Diet Supplemented with Excess Pyrroloquinoline Quinone Disodium on Growth Performance and Blood Parameters...Animals (Basel). 2021;11(2):411.
- Three Potential Pet Nutrients - PQQ, Coenzyme Q10 and S-adenosylmethionine. GSHWORLD. Available from: https://www.gsh-world.com/news/Three-Potential-Pet-Nutrients-PQQ-Coenzyme-Q10-and-S-adenosylmethionine.html.
- Della Rocca G, Gamba D. Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide? Animals (Basel). 2021;11(4):952.
- Scarampella F, Fiori F, Abramo F, et al. Palmitoylethanolamide and Related ALIAmides for Small Animal Health: From Endogenous Metabolites to New Pharmaceutical Perspectives. Animals (Basel). 2022;12(18):2403.
- Palmitoylethanolamide (PEA) and related amides and the cavalier King Charles spaniel. CavalierHealth.org. Available from: https://www.cavalierhealth.org/pea.htm.