Stiffness or soreness
When movement seems less comfortable after activity or rest.
PEA FOR DOGS
Your Dog Is Uncomfortable. What Can You Do About It?
Maybe it started after a rough day of activity.
Maybe getting up seems harder.
Maybe your dog is moving more carefully than usual.
Maybe they're constantly licking, scratching, or dealing with seasonal or topical allergies.
More and more research is pointing to one active ingredient worth knowing about.
It’s called PEA.
WHAT IS PEA?
Meet PEA
Palmitoylethanolamide
PEA is a naturally occurring fatty-acid compound that your dog's body already produces. It's been researched for decades in both humans and dogs.
PEA is involved in biological processes related to maintaining nervous and immune system balance and responding to stress in tissues, which is why veterinarians have become interested in supplemental PEA for dogs.
Research has looked at PEA in areas including:
- Everyday Comfort
- Movement & Mobility
- Healthy Inflammatory Response
- Skin Health
PEA OVERVIEWRESEARCH AREAS
Everyday Comfort
Movement & Mobility
PEAPalmitoylethanolamide
Healthy Inflammatory Response
Skin Health
2026 CLINICAL RESEARCH
A Recent Study Put PEA to the Test in Dogs
In 2026, researchers published a randomized, double-blind, placebo-controlled study involving 50 dogs with joint discomfort.
Over six weeks, the dogs received either a PEA formulation or a placebo.
The PEA formulation was also well tolerated during the study.
76%
of dogs receiving PEA met the study's criteria for successful treatment
compared with 40% of dogs receiving placebo
Getting up from lying down
Walking
Running
General activity
BEYOND MOBILITY
PEA Has Also Been Studied for Skin Health
PEA research in dogs is not limited to movement and mobility.
Researchers have also studied PEA in dogs experiencing itching and skin-related concerns, including seasonal and topical allergy-related issues. [2]
Separate laboratory research has looked at how PEA interacts with biological activity in canine skin tissue. [3]
The strength of the evidence varies by study, but together it helps explain why PEA is attracting interest across several different areas of canine comfort.
Skin Health
Healthy Inflammatory Response
Everyday Comfort
WHERE PEA MAY FIT
When Might PEA Be Worth Looking Into?
PEA may be worth learning about if your dog is dealing with things like:
Reduced mobility
When your dog is moving more slowly, more carefully, or with less ease.
Discomfort after activity
When a hard day of play, exercise, or physical activity seems to take more out of them.
Difficulty getting comfortable
When your dog seems restless, shifts positions often, or takes longer to settle.
Itchy or sensitive skin
When recurring itching, scratching, or skin sensitivity becomes part of everyday life.
Seasonal or topical allergies
When environmental or contact-related triggers seem to affect your dog's skin comfort.
PEA is not a treatment for any disease or condition. But the research points to PEA as an effective option for managing many of the normal aches and pains of life.
CHOOSING A PEA PRODUCT
If You Want to Try PEA, Look at More Than the Front of the Label
Once you start comparing PEA products, three details are especially worth paying attention to.
What form of PEA does it use?
PEA does not dissolve easily in water, which is one reason particle size matters.
Micronization reduces PEA into smaller particles, increasing surface area and helping it dissolve more readily. [4]
Look for micronized PEA when comparing products.
How much PEA are you actually getting?
An ingredient can appear on a label without being the real focus of the formula.
Some supplements include PEA as one ingredient among many. Others are built around it more deliberately.
Check the actual amount of PEA per serving, not just whether PEA appears on the label.
Is the PEA responsibly sourced?
PEA can be made using palm-derived fatty acids, including fatty acids sourced from palm kernels.
Palm production has been associated with deforestation, habitat loss, and other environmental impacts when it is not managed responsibly.
Look for PEA sourced through companies that participate in the Roundtable on Sustainable Palm Oil (RSPO) or use certified sustainable palm sources.
Form, amount, and sourcing were all part of the decision-making when we built Amiquip.
INTRODUCING AMIQUP®
Amiquip Was Built Around PEA
Amiquip provides 200 mg of micronized PEA per full chew.
We paired it with just one other active ingredient, 6 mg of PQQ, selected to support cellular vitality, natural energy, and healthy aging.
200 mg
Micronized PEA per full chew
Supports everyday comfort, movement, skin health, and healthy inflammatory response.
6 mg
PQQ per full chew
Supports cellular vitality, natural energy, and healthy aging.
The idea is simple: two active ingredients that address two primary foundations: a healthy inflammatory response and cellular vitality.
That means whole-body comfort in the short term, and healthy aging over time.
Ready to try PEA for your dog?
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AFTER 6 WEEKS, MANY OWNERS REPORTED:
LONGER
WALKS
MORE PLAYFUL
BEHAVIOR
EASIER
MOVEMENT
IMPROVED
QUALITY OF LIFE
THE RESEARCH
References
- [1] Briskey D, Craddock E, Rao A, Mills PC. Levagen+ (palmitoylethanolamide) alleviates joint pain and reduces the impact of joint pain in canines and felines: a double-blind, placebo-controlled, randomized clinical trial. Frontiers in Veterinary Science. 2026;13:1703143. doi:10.3389/fvets.2026.1703143.
- [2] Noli C, et al. Efficacy of ultra-micronized palmitoylethanolamide in canine atopic dermatitis: an open-label multi-centre study. Veterinary Dermatology. 2015. doi:10.1111/vde.12250.
- [3] Abramo F, et al. Ultramicronized palmitoylethanolamide counteracts the effects of compound 48/80 in a canine skin organ culture model. Veterinary Dermatology. 2017. doi:10.1111/vde.12456.
- [4] Gabrielsson L, Mattsson S, Fowler CJ. Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. British Journal of Clinical Pharmacology. 2016;82:932-942.